"Parkinson’s disease (PD) is a movement disorder characterized by tremor, rigidity, akinesia, and loss of posture reflexes, which leads to immobility and frequent falls. PD results from the selective loss of dopaminergic (DA) neurons in the substantia nigra (SN) of the brain. Recent studies highlight a possible relationship between thiamine and PD. Thiamine may be beneficial for PD patients. Lower central nervous system (CSF)-free thiamine levels were noted in PD patients compared with the controls."